Clean It Time

Defraggler and CCleaner both made by Piriform (both free programs).

CCleaner is a freeware system optimization and privacy tool. It removes unused files from your system – allowing Windows to run faster and freeing up valuable hard disk space. It also cleans traces of your online activities such as your Internet history. CCleaner also fixes your registry. But the best part is that it’s fast (normally taking less than a second to run) and contains NO Spyware or Adware.

There’s no point to pay for a defrager. The increase in performance will be hardly noticeable. The best thing you can do is to increase your RAM.

Crucial memory advisor: http://www.crucial.com
References :
http://www.ccleaner.com
http://www.defraggler.com/

This one:

http://www.ccleaner.com/
References :

I use desktop meastro and spyware doctor. It does everything you need, though i have heard that Regcure is the best one you can get, I ran the trial of regcure and it found almost 800 false entries within my reg files.
(I already had maestro by that point though)
References :

When you have TuneUp Utilites 2009, you already have a very good registry cleaner and registry defrag program.
You do no really need anything else.

Just in case you like to try another registry cleaner, you should install the best free and safe to use cleaner
Comodo Registry Cleaner
http://registry-cleaner.comodo.com/

When you do not mean registry defrager, but a normal hard disk defrager, I have 2 very good free programs.

Two of the best free defrag programs
http://www.download.com/Auslogics-Disk-Defrag/3000-2094_4-10567503.html
http://www.snapfiles.com/reviews/iobit-smartdefrag/iobitsmartdefrag.html

http://www.iobit.com/advancedwindowscareper.html
It is free
References :

The best defragmenters in my opinion are either Raxco PerfectDisk
http://www.perfectdisk.com/products/home-perfectdisk10-home-edition/learn-more
or my preferred choice O&O Defrag
http://www.oo-software.com/home/en/products/oodefrag/index.html

although Jk DefragGUI is free and worth checking out.

Best Registry Repair tool – hard to say – I do like Comodo Registry Repair as mentioned above because it points out registry entries that should not be deleted and auto backs up the registry before repairing – not bad for free!
I do like Registry Mechanic because it is reliable and has a good user interface
http://www.pctools.com/registry-mechanic/
and I have also used Amust Registry Cleaner which is good too
http://www.amustsoft.com/registrycleaner/

Reg Organizer is a comprehensive registry tool
http://www.chemtable.com/organizer.htm
References :

well without any doubt i highly reccommend jv16 PowerTools 2009. It made my pc works faster and loads faster. It has lot of tools to address each problem uniquely and i think other mentioned softwares don’t have them.

By the way what i love most about it is, It’s file recovery tool.Very useful! Here are it’s features and i’ll put a download link for you ro try.

* Software Uninstaller
* Startup Manager
* Registry Manager
* Registry Cleaner
* Registry Finder
* Registry Find and Replace
* Registry Monitor
* Registry Compactor
* Registry Information
* File Finder
* File Cleaner
* File Organizer

* File Recovery
* Duplicate File Finder
* File Tool
* Directory Finder
* Directory Tool
* Disk Wiper
* Service Manager (New!!)
* System Cleaner
* System Optimizer (New!!)
* Start Menu Tool
* History Cleaner
* Automation Tool
References :
http://www.macecraft.com/jv16powertools2009/